2020年研究成果

  1. Uzawa H, Kohno D, Koga T, Sasaki T, Fukunaka A, Okuno T, Watanabe A.J, Kazuno S, Miyatsuka T, Kitamira T, Fujitani Y, Watada H, Saeki K and Yokomizo T. Leukotriene A4 hydrolase deficiency protects mice from diet-induced obesity by increasing energy expenditure through neuroendocrine axis. FASEB 34: 13949-13958, 2020.
  2. Sato Y, Rahman M.M, Haneda M, Tsuyama T, Mizumoto T, Yoshizawa T, Kitamura T, Gonzalez F.J, Yamamura K, Yamagata K. HNF1a controls glucagon secretion in pancreatic alpha cells through modulation of SGLT1. Biochim Biophys Acta Mol Basis Dis 1866: 165898, 2020.
  3. Suga T, Sato K, Ohyama T, Matsui S, Kobayashi T, Tojima H, Horiguchi N, Yamazaki Y, Kakizaki S, Nishikido A, Okamura T, Yamada M, Kitamura T, Uraoka T. Ipragliflozin-induced improvement of liver steatosis in obese mice may involve sirtuin signaling. World J of Hepatol 12: 350-362, 2020.
  4. Nakai S, Oyabu M, Hatazawa Y, Akashi S, Kitamura T, Miura S, Kamei Y. FOXO1 suppresses PGC-1β gene expression in skeletal muscles. FEBS Open Bio 10: 1373-1388, 2020.
  5. Kobayashi M, Waki H, Nakayama H, Miyachi A, Mieno E, Hamajima H, Goto M, Yamada K, Yamauchi T, Kadowaki T, Kitamura T. Pseudo-hyperglucagonemia was observed in the pancreatectomized cases when measured by glucagon sandwich ELISA. J Diabetes Investig. in press.
  6. Kobayashi M, Satoh H, Matsuo T, Kusunoki Y, Tokushima M, Watada H, Namba M, Kitamura T. Plasma glucagon levels measured by sandwich ELISA are correlated with impaired glucose tolerance in type 2 diabetes. Endocr J 67: 903-922, 2020.
  7. Hosooka T, Hosokawa Y, Matsugi K, Shinohara M, Senga Y, Tamori Y, Aoki C, Matsui S, Sasaki T, Kitamura T, Kuroda M, Sakaue H, Nomura K, Yoshino K, Nabatame Y, Itoh Y, Yamaguchi K, Hayashi Y, Nakae J, Accili D, Yokomizo T, Seino S, Kasuga M, Ogawa W. The PDK1-Foxo1 signaling in adipocytes controls systemic insulin sensitivety through the 5-lipoxygenase-leukotrien B4 axis. Proc Natl Acad Sci U S A. 117: 11674-11684, 2020.
  8. Kodani N, Nakae J, Kobayashi M, Kikuchi O, Kitamura T, Itoh H. FCoR-Foxo1 Axis Regulates a-cell Mass through Repression of Arx iScience 23: 100798, 2020.
  9. Kuroda M, Onoyama R, Sasaki W, Sebe M, Kitamura T, Masumoto S, Tsutsumi R, Harada N, Sakaue H. DNA methylation status influences insulin-induced glucose transport in 3T3-L1 adipocytes by mediating p53 expression. BBRC 525: 39-45, 2020.
  10. Kohno D, Furusawa K, Kitamura T. Anagliptin suppresses diet-induced obesity through enhancing leptin sensitivity and ameliorating hyperphagia in high-fat high-sucrose diet fed mice. Endocr J 67: 523-529, 2020.
  11. 北村 忠弘, 綿田 裕孝, 長坂 昌一郎, 石原 寿光, 柴 輝男, 植木 浩二郎, 難波 光義　2020. グルカゴン測定法検証のための委員会報告―新たな測定法によるグルカゴン値は糖尿病病態の把握に役立つ―　糖尿病
  12. 北村忠弘　2020. グルカゴン分泌異常　月刊糖尿病DIABETES
  13. 北村忠弘　2020. SGLT2とグルカゴン分泌　糖尿病•内分泌代謝科

    2019年研究成果

    1. Inaba Y, Hashiguchi E, Watanabe H, Kimura K, Sato M, Kobayashi M, Matsumoto M, Kitamura T, Kasuga M, Inoue H. Heapatic gluconeogenic response to single and long-term SGLT2 inhibition in lean/obese male hepatic G6pc-reporter mice. Endocrinology 160: 2811-2824, 2019.
    2. Toba K, Hosojima M, Kabasawa H, Kuwahara S, Murayama T, Yamamoto-Kabasawa K, Kaseda R, Wada E, Watanabe R, Tanabe N, Suzuki Y, Narita I, Saito A. Higher estimated net endogenous acid production with lower intake of fruits and vegetables based on a dietary survey is associated with the progression of chronic kidney disease. BMC Nephrol 20: 421, 2019.
    3. Honzawa N, Fujimoto K, Kitamura T. Cell autonomous dysfunction and insulin resistance in pancreatic alpha cells. Int Mol Sci 20: E3699, 2019.
    4. Ichikawa R, Takanao K, Fujimoto K, Motomiya T, Kobayashi M, Kitamura T, Shichiri M. Basal glucagon hypersecretion and response to oral glucose load in prediabetes and mild type 2 diabetes. Endocr J. 66: 663-675, 2019.
    5. Suga T, Kikuchi O, Kobayashi M, Matsui S, Yokota-Hashimoto H, Wada E, Kohno D, Sasaki T, Takeuchi K, Kakizaki S, Yamada M, *Kitamura T. 2019. SGLT1 in pancreastic a cells regulates glucagon secretion in mice, possibly explaining the distinct effects of SGLT2 inhibitors on plasma glucagon levels. Mol Metab 19: 1-12.
    6. 北村忠弘　2019. グルカゴン研究における最近の進歩　日本内科学会雑誌　１０８巻第１０号　医学と医療の最前線
    7. 北村忠弘　2019. SGLT2阻害薬とグルカゴン分泌　月刊糖尿病DIABETES
    8. 北村忠弘　2019. サンドイッチELISAと質量分析を用いたグルカゴン測定法　内分泌•糖尿病•代謝内科
    9. 北村忠弘　2019. 肝臓のグルタミナーゼ活性を標的にして、高血糖を是正する　Diabetes Update
    10. 北村忠弘　2019. グルカゴン研究の重要性と将来展望　循環器内科

    2018年研究成果

    1. Matsui S, *Sasaki T, Kohno D, Yaku K, Inutsuka A, Yokota-Hashimoto H, Kikuchi O, Suga T, Kobayashi M, Yamanaka A, Harada A, Nakagawa T, Onaka T, Kitamura T. 2018. Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signaling in mice. Nat Communi 9: 4604-4620.
    2. Gulshan M, Yaku K, Okabe K, Mahmood A, Sasaki T, Yamamoto M, Hikosaka K, Usui I, Kitamura T, Tobe K, *Nakagawa T. 2018. Overexpression of Nmnat3 efficiently increases NAD and NGD levels and ameliorates age-associated insulin resistance. Aging Cell 17: e12798.
    3. *Sasaki T, Numano R, Yokota-Hashimoto H, Matsui S, Kimura N, Takeuchi H, Kitamura T. 2018. A central-acting connexin inhibitor, INI-0602, prevents high-fat diet-induced feeding pattern disturbances and obesity in mice. Mol Brain 11: 28.
    4. Kato T, *Iizuka K, Takao K, Horikawa Y, Kitamura T, Takeda J. 2018. ChREBP-knockout mice show sucrose intolerance and fructose malabsorption. Nutrients 10: E340.
    5. *Torii S, Kubota C, Saito N, Kawano A, Hou N, Kobayashi M, Torii R, Hosaka M, Kitamura T, Takeuchi T, Gomi H. 2018. The pseudophosphatase phogrin enables glucose-stimulated insulin signaling in pancreatic beta vells. J Biol Chem 293: 5920-5922.
    6. 北村忠弘、小林雅樹　2018. サンドイッチELISAを用いたグルカゴン再検証の必要性　和光純薬時報
    7. 北村忠弘　2018. グルカゴン測定系　糖尿病
    8. 北村忠弘　2018. インスリン／グルカゴン　シグナリング　代謝センシングー健康、食、美容、薬、そして脳の代謝を知るー第５章
    9. 菊池唯史、北村忠弘、難波光義　2018. グルカゴンELISA測定キットの性能評価　医学と薬学
    10. 北村忠弘　2018. グルカゴンの新規測定法　内分泌•糖尿病•代謝内科
    11. 小林雅樹　2018. グルカゴン　比較内分泌学

    2017年研究成果

    1. Fukunaka A, Fukada T, Bhin J, Suzuki L, Tsuzuki T, Takamine Y, Bin BH, Yoshihara T, Ichinoseki-Sekine N, Naito H, Miyatsuka T, Takamiya S, Sasaki T, Inagaki T, Kitamura T, Kajimura S, Watada H, *Fujitani Y. 2017. Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-β expression. PLoS Genet 13: e1006950.
    2. Emoto R, Kurosawa A, Nikaido Y, Mashiko M, Saheki T, Nakajima N, Kuroiwa S, Otobe M, Ohsaki M, Tooyama K, Inoue Y, Kuwabara N, Kikuchi O, Kitamura T, Kojima I, Nakagawa Y, Saito T, Osada H, Futahashi M, Sezutsu H, *Takeda S. 2017. A novel partial agonist of GPBA reduces blood glucose level in a murine glucose tolerance test. Euro J Pharma 814: 130-137.
    3. *Sasaki T, Yoshimasa Y, Matsui S, Yokota-Hashimoto H, Kobayashi M, Kitamura T. 2017. Intraperitoneal injection of D-serine suppresses high-fat diet intake and preference in male mice. Appetite 118: 120-128.
    4. *Miyachi A, Kobayashi M, Mieno E, Goto M, Furusawa K, Inagaki T, *Kitamura T. 2017. Accurate analytical method for human plasma glucagon levels using liquid chromatography-high resolution mass spectrometry: Comparison with commercially available immunoassays. Anal Bioanal Chem 409: 5911-5918.
    5. 北村忠弘　2017. グルカゴン•ルネッサンス　BIOS
    6. 北村忠弘　2017. グルカゴン•ルネッサンス　糖尿病学２０１７
    7. 北村忠弘　2017. エネルギー代謝と肥満（エネルギーを使わないと肥満になる）　肥満と疾患〜どこまで解明されたか〜
    8. 北村忠弘、小林雅樹　2017. グルカゴン分泌異常—その病態生理的意義　実験医学　増刊（糖尿病）
    9. 和田恵梨、細島康宏、蒲澤秀門、石川友美、桑原頌治、忰田亮平、成田一衛、本間則行、鈴木芳樹、斎藤亮彦　2017. SGLT2阻害薬開始の前後で食事記録を確認できた肥満2型糖尿病の一例　日本病態栄養学会誌

    2016年研究成果

    1. *Kohno D, Koike M, Ninomiya Y, Kojima I, Kitamura T, Yada T. 2016. Sweet taste receptor serves to activate glucose- and leptin-responsive neurons in the hypothalamus arcuate nucleus and participates in glucose responsiveness. Front Neurosci 10: 502.
    2. Miyatake Y, Shiuchi T, Mawatari K, Toda S, Taniguchi Y, Futami A, Sato F, Kuroda M, Sebe M, Tsutsumi R, Harada N, Minokoshi Y, Kitamura T, Gotoh K, Ueno M, Nakaya Y, *Sakaue H. 2016. Intracerebroventricular injection of ghrelin decreases wheel running activity in rats. Peptides 87: 12-19.
    3. Kuroda M, Tominaga A, Nakagawa K, Nishiguchi M, Sebe M, Miyatake Y, Kitamura T, Tsutsumi R, Harada N, Nakaya Y, *Sakaue H. 2016. DNA methylation suppresses leptin gene in 3T3-L1 adipocytes. PloS ONE 11: e0160532.
    4. Kunii M, Ohara-Imaizumi, Takahashi N, Kobayashi M, Kawakami R, Kondoh Y, Shimizu T, Simizu S, Lin B, Nunomura K, Aoyagi K, Ohno M, Ohmuraya M, Sato T, Yoshimura S, Sato K, Harada R, Kim Y-J, Osada H, Nemoto T, Kasai H, Kitamura T, Nagamatsu S, *Harada A. 2016. Opposing roles for SNAP23 in secretion in exocrine and endocrine pancreatic cells J Cell Biol 215: 121-138.
    5. *Sasaki T, Matsui S, Kitamura T. 2016. Control of appetite and food preference by NMDA receptor and its co-agonist D-serine. Int J Mol Sci 17: E1081.
    6. Ghanem S, Heinrich G, Lester S, Pfeiffer V, Bhattacharya S, Patel P, DeAngelis A, Dai T, Ramakrishnan S, Smiley Z, Jung D, Lee Y, Kitamura T, Ergun S, Kulkarni R, Kim J, Giovannucci D, *Najjar S. 2016. Increased glucose-induced secretion of glucagon-like peptide-1 in mice lacking the carcino-embryonic antigen-related cell adhesion molecule 2. J Biol Chem 291: 980-988.
    7. 北村忠弘、小林雅樹　2016. 栄養素によるグルカゴン、インスリンの変動と糖尿病との関連　実験医学　増刊（栄養素シグナル）
    8. 佐々木努、北村忠弘　2016. 肥満と糖尿病の表現型解析　実験医学別冊マウス表現型解析スタンダード　
    9. 北村忠弘　2016. 糖尿病治療におけるグルカゴンの重要性　医療情報誌Schneller
    10. 北村忠弘　2016. 新しい標的、グルカゴン受容体とその拮抗薬の開発　月刊糖尿病Diabetes
    11. 北村忠弘　2016. 特異的グルカゴン測定キットの開発　—真のグルカゴン値の測定による病態解明—　Medical Science Digest
    12. 北村忠弘　2016. 膵β細胞の脱分化　糖尿病
    13. 北村忠弘　2016. グルカゴンー最新の知見—　Diabetes Journal
    14. 北村忠弘　2016. SU薬の作用機序を教えて下さい、グルカゴンに対する影響を教えて下さい　糖尿病治療薬クリニカルクエッション
    15. 北村忠弘　2016. グルカゴン測定の課題　診断と治療増刊号
    16. 北村忠弘　2016. DPP4阻害薬　Medicina

    2015年研究成果

    1. *Sasaki T, Kinoshita Y, Matsui S, Kakuta S, Yokota-Hashimoto H, Kinoshita K, Iwasaki Y, Kinoshita T, Yada T, Amano N, Kitamura T. 2015. N-methyl D-aspartate receptor co-agonist D-serine suppresses intake of high-preference food. Am J Physiol Regul Integr Comp Physiol 309: R561-575.
    2. Sasaki T, Kuroko M, Sekine S, Matsui S, Kikuchi O, Susanti VY, Kobayashi M, Tanaka Y, Yuasa T, *Kitamura T. 2015. Overexpression of insulin receptor partially improves obese and diabetic phenotype in db/db mice. Endcr J 62: 787-796.
    3. Miyatake Y, Shiuchi T, Ueta T, Taniguchi Y, Futami A, Sato F, Kitamura T, Tsutsumi R, Harada N, Nakaya Y, *Sakaue H. 2015. Intracerebroventricular injection of adiponectin regulates locomoter activity in rats. J Med Invest 62: 199-203.
    4. Sasaki T, Hiraga H, Yokota-Hashimoto H, *Kitamura T. 2015. Miglitol protects against age-dependent weight gain in mice: A potential role of increased UCP1 content in brown adipose tissue. Endcr J 62: 469-473.
    5. Cook JR, Matsumoto M, Banks AS, Kitamura T, Tsuchiya K, *Accili D. 2015. A mutant allele encoding DNA-binding-deficient Foxo1 differentially regulates hepatic glucose and lipid metabolism. Diabetes 64: 1951-1965.
    6. 北村忠弘　2015. ラ氏島細胞研究Update　ホルモンと臨床
    7. 北村忠弘　2015. グルカゴン測定系の課題とアプローチ　Diabetes Frontier
    8. 北村忠弘　2015. SGLT2阻害による血中グルカゴン濃度増加　ホルモンと臨床
    9. 北村忠弘　2015. エイジングとホルモン（５）インスリン　HORMONE FRONTIER IN GYNECOLOGY
    10. 北村忠弘　2015. これからの糖尿病治療戦略〜新しい経口糖尿病薬をどう使うか〜　高崎医学
    11. 北村忠弘、北村ゆかり　2015. 各臓器におけるFOXO1の代謝作用　生化学
    12. 北村忠弘　2015. 糖尿病におけるグルカゴンの意義　糖尿病診療マスター
    13. 北村忠弘　2015. STGL2阻害薬の投与によってグルカゴンはなぜ上昇するのか！？　Diabetes Strategy
    14. 北村忠弘　2015. グルカゴン　日常臨床のための検査値のみかた
    15. 北村忠弘、小林雅樹　2015. 概論—グルカゴンが糖尿病学•医療にもたらした革命とは？　実験医学　特集号（グルカゴン革命）
    16. 北村忠弘　2015. 新たな治療標的と創薬　グルカゴンとグルカゴン受容体　Mebio
    17. 北村忠弘　2015. 糖尿病治療におけるグルカゴン制御の重要性　日本臨床

    2014年研究成果

    1. Kohno D, Lee S, Harper MJ, Kim KW, Sone H, Sasaki T, Kitamura T, Fan G, *Elmquist JK. 2014. Dnmt3a in Sim1 neurons is necessary for normal energy homeostasis. J Neurosci 34: 15288-15296.
    2. Yoshino S, *Satoh T, Yamada M, Hashimoto K, Tomaru T, Katano-Toki A, Kakizaki S, Okada S, Shimizu H, Ozawa A, Tuchiya T, Ikota H, Nakazato Y, Mori M, Matozaki T, Sasaki T, Kitamura T, Mori M. 2014. Protection against high-fat diet-induced obesity in Helz2-deficient male mice due to enhanced expression of hepatic leptin receptor. Endocrinology 155: 3459-3472.
    3. Susanti V-Y, *Sasaki T, Yokota-Hashimoto H, Matsui S, Lee Y-S, Kikuchi O, Shimpuku M, Kim H-J, Kobayashi M and *Kitamura T. 2014. Sirt1 reverses the obesity by insulin-resistant constitutively-nuclear FoxO1 in POMC neurons of male mice. Obesity 10: 2115-2119.
    4. Usui T, Kajita K, Kajita T, Mori I, Hanamoto T, Ikeda T, Okada H, Taguchi K, Kitada Y, Morita H, Sasaki T, Kitamura T, Sato T, Kojima I, Ishizuka T. 2014. Elevated mitochondrial biogenesis in skeletal muscle is associated with testosterone-induced body weight loss in male mice. FEBS Lett 588: 1935-1941.
    5. Takamoto I, Kubota N, Nakaya K, Kumagai K, Hashimoto S, Kubota T, Inoue M, Kajiwara E, Katsuyama H, Obata A, Sakurai Y, Iwamoto M, Kitamura T, Ueki K and *Kadowaki T. 2014. TCF7L2 in pancreatic beta cells plays crucial roles in glucose homeostasis by regulating beta-cell mass. Diabetologia 57: 542-553.
    6. Sasaki T, Kikuchi O, Shimpuku M, Susanti V-Y, Yokota-Hashimoto H, Taguchi R, Shibusawa N, Sato T, Tang L, Amano K, Kitazumi T, Kuroko M, Fujita Y, Maruyama J, Lee Y-S, Kobayashi M, Nakagawa T, Minokoshi Y, Harada A, Yamada M and *Kitamura T. 2014. Hypothalamic Sirt1 prevents age-associated weight gain by improving leptin sensitivity in mice. Diabetologia 57: 819-831.
    7. Lee Y-S, Kobayashi M, Kikuchi O, Sasaki T, Kim H-J, Yokota-Hashimoto H, Susanti V-Y, Ido-Kitamura Y and *Kitamura T. 2014. ATF3 expression is induced by low glucose in pancreatic alpha and beta cells and regulates glucagon but not insulin gene transcription. Endocr J 61: 85-90.
    8. 北村忠弘　2014　GLP-1はどのようにしてグルカゴンを抑制するのか　内分泌•糖尿病•代謝内科
    9. 北村忠弘、小林雅樹　2014　グルカゴン測定系の確立の歴史と問題点　内分泌•糖尿病•代謝内科
    10. 北村忠弘　2014　エネルギーホメオスターシスとFoxO1、Sirt1　最新肥満症学
    11. 北村忠弘　2014　FoxO1を介した膵β細胞の脱分化　内分泌•糖尿病•代謝内科
    12. 北村忠弘　2014　インスリンシグナルによる老化制御とアンチエイジング　最新医学
    13. 北村忠弘　2014　α細胞の解剖学、発生学　Diabetes Frontier
    14. 北村忠弘　2014　グルカゴン•ルネッサンス　実験医学
    15. 北村忠弘　2014　膵β細胞の分化、脱分化による量の調節機構　Annual Review 糖尿病•代謝•内分泌2014

    2013年研究成果

    1. Syamsunarno MA, *Iso T, Hanaoka Y, Yamaguchi A, Obokata M, Koitabashi N, Goto K, Hishiki T, Nagahata Y, Matsui H, Sano M, Kobayashi M, Kikuchi O, Sasaki T, Maeda K, Murakami M, Kitamura T, Suematsu M, Tsushima Y, Endo K, Hotamisligil GS, Kurabayashi M. 2013. A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting. PLoS ONE 8: e79386.
    2. Fukaya M, Tamura Y, Chiba Y, Tanioka T, Mao J, Inoue Y, Yamada M, Waeber C, Ido-Kitamura Y, Kitamura T, *Kaneki M. 2013. Protective effects of a nicotinamide derivative, isonicotinamide, against streptozotocin-induced beta-cell damage and diabetes in mice. Biochem Bioph Res Co 442: 92-98.
    3. *Kitamura T. 2013. The role of FOXO1 in β-cell failure and type 2 diabetes mellitus. Nat Rev Endo 9: 615-623.
    4. Lee Y-S, Sasaki T, Kobayashi M, Kikuchi O, Kim H-J, Yokota-Hashimoto H, Shimpuku M, Susanti V-Y, Ido-Kitamura Y, Kimura K, Inoue H, Tanaka-Okamoto M, Ishizaki H, Miyoshi J, Ohya S, Tanaka Y, Kitajima S and *Kitamura T. 2013. Hypothalamic ATF3 is involved in regulating glucose and energy metabolism. Diabetologia 56: 1383-1393.
    5. Masubuchi Y, Nakagawa Y, Ma J, Sasaki T, Kitamura T, Yamamoto Y, Kurose H, Kojima I, Shibata H. 2013. A novel regulatory function of sweet taste-sensing receptor in adipogenic differentiation of 3T3-L1 cells. PLoS ONE 8: e54500.
    6. 北村忠弘　2013　膵β細胞量の調節機構　内科
    7. 北村忠弘　2013　グルカゴン　ホルモンと臨床
    8. 北村忠弘　2013　膵β細胞量の調節におけるFoxO1の役割　Islet Equality
    9. 北村忠弘　2013　TOPICS糖尿病における膵β細胞機能不全のメカニズムとしてのβ細胞脱分化　Diabetes Strategy
    10. 北村忠弘　2013　海外文献紹介　Diabetes Frontier
    11. 北村忠弘　2013　変わりつつある糖尿病治療戦略について考える　高崎医学
    12. 北村忠弘　2013　消化管におけるFoxO1抑制による機能性インスリン産生細胞の樹立　糖尿病学2013　1-10.
    13. 北村忠弘　2013　 FoxO1による腸管内分泌細胞分化制御　内分泌•糖尿病•代謝内科　36: 211-219.
    14. 北村忠弘　2013　肥満と中枢性エネルギー代謝調節機構　日本臨床　特集：肥満症　71: 217-223.

    2012年研究成果

    1. Kitamura YI, Sasaki T, Kobayashi M, Kim H-J, Lee Y-S, Kikuchi O, Yokota-Hashimoto H, Iizuka K, Accili D, *Kitamura T. 2012. Hepatic FoxO1 Integrates Glucose Utilization and Lipid Synthesis Through Regulation of Chrebp O-glycosylation. PLoS ONE 7: e47231.
    2. Nakakura T, Mogi C, Tobo M, Tomura H, Sato K, Kobayashi M, Ohnishi H, Tanaka S, Wayama M, Sugiyama T, Kitamura T, Harada A, Okajima F. 2012. Deficiency of Proton-Sensing Ovarian Cancer G Protein-Coupled Receptor 1 Attenuates Glucose-Stimulated Insulin Secretion. Endocrinology 153: 4171-4180.
    3. Hasegawa K, Kawahara T, Fujiwara K, Shimpuku M, Sasaki T, Kitamura T, Yoshikawa K. 2012. Necdin controls Foxo1 acetylation in hypothalamic arcuate nucleus to modulate the thyroid axis. J Neuroscience 32: 5562-5572.
    4. Talchai C, Xuan S, Kitamura T, Depinho RA, Accili D.2012. Generation of functional insulin-producing cells in the gut by Foxo1 ablation. Nat Genet 44: 406-412.
    5. Kikuchi O, Kobayashi M, Amano K, Sasaki T, Kitazumi T, Kim H-J, Lee Y-S, Yokota-Hashimoto H, Kitamura Y-I and *Kitamura T. 2012. FoxO1 Gain of Function in the Pancreas Causes Glucose Intolerance, Polycystic Pancreas, and Islet Hypervascularization. PLoS ONE 7: e32249.
    6. Kobayashi M, Kikuchi O, Sasaki T, Kim HJ, Yokota-Hashimoto H, Lee YS, Amano K, Kitazumi T, Susanti VY, Kitamura YI, *Kitamura T. 2012. FoxO1 as a Double-edged Sword in the Pancreas: Analysis of Pancreas and β Cell-specific FoxO1 Knockout Mice. Am J Physiol Endocrinol Metab. 302: E603-613.
    7. Kim H-J., Kobayashi M., Sasaki T., Kikuchi O., Amano K., Kitazumi T., Lee Y-S., Yokota-Hashimoto H., Susanti V-Y., Ido-Kitamura Y., Nakae J. and *Kitamura T. 2012. Over-expression of FoxO1 in the Hypothalamus and Pancreas Causes Obesity and Glucose Intolerance. Endocrinology 153: 659-671.
    8. *Kitamura T. and Sasaki T. 2012. Hypothalamic Sirt1 and regulation of food intake. Diabetology International 3: 109-112.
    9. Kim KW, Donato J Jr, Berglund ED, Choi YH, Kohno D, Elias CF, DePinho RA, Elmquist JK. 2012. FoxO1 Regulates Energy Balance and Glucose Homeostasis in Neurons in the Ventral Medial Nucleus of the Hypothalamus. J Clin Invest 122: 2578-2589.
    10. Kohno D, Yada T. 2012. Arcuate NPY neurons sense and integrate peripheral metabolic signals to control feeding.　Neuropeptides 46: 315-319.

    2011年研究成果

    1. Tanioka T., Tamura Y., Fukaya M., Shinozaki S., Mao J., Kim M., Shimizu N., Kitamura T. and Kaneki M. 2011. iNOS and NO donor decrease IRS-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta cells: involvement of GSK-3b. J. Biol. Chem. 286: 29388-29396.
    2. Hirata M., Suzuki M., Ishii R., Kitazumi T., Sasaki T., Kitamura T., Yamaguchi H., Nakamura Y. and Fukami K. 2011. Genetic defect in phospholipase Cδ1 protects mice from obesity by regulating thermogenesis and adipogenesis. Diabetes 60: 1926-1937.
    3. Maejima Y, Kohno D, Iwasaki Y, Yada T.2011. Insulin suppresses ghrelin-induced calcium signaling in neuropeptide Y neurons of the hypothalamic arcuate nucleus. Aging (Albany NY) 3:1092-1097.
    4. Chuang JC, Sakata I, Kohno D, Perello M, Osborne-Lawrence S, Repa JJ, Zigman JM. 2011. Ghrelin Directly Stimulates Glucagon Secretion from Pancreatic α-Cells. Mol Endocrinol. 25:1600-1611.
    5. Kohno D, Sone H, Tanaka S, Kurita H, Gantulga D, Yada T. 2011. AMP-activated protein kinase activates neuropeptide Y neurons in the hypothalamic arcuate nucleus to increase food intake in rats. Neurosci Lett. 499, 194-198.
    6. Kim KW, Zhao L, Donato J Jr, Kohno D, Xu Y, Elias CF, Lee C, Parker KL, Elmquist JK. 2011. Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus. Proc Natl Acad Sci U S A 108, 10673-10678.
    7. 北村忠弘　2011　 FoxO1とエネルギー代謝　BIO Clinica　 26: 18-24.
    8. 北村忠弘 2011　膵β細胞の分化、増殖制御と糖尿病治療　細胞　43: 2-4.
    9. 北村忠弘、佐々木努　2011　POMC/CART（視床下部におけるFoxO1とSirt1）生体の科学　62: 26-30.
    10. 北村忠弘、北村ゆかり 2011　PPARファミリー、C/EBPファミリー、FoxOファミリー　日本臨床・増刊号メタボリックシンドローム　69: 259-263.
    11. *Kitamura T. , Kitamura Y., Accili D. 2011. Role of FoxO1 proteins in pancreatic b cells. Islet Cell Growth Factors. Chapter 6, 73-83.

    2010年研究成果

    1. Kaneko K., Ueki K., Takahashi N., Hashimoto S., Okamoto M., Awazawa M., Okazaki Y., Ohsugi M., Inabe K., Umehara T., Yoshida M., Kakei M., Kitamura T., Luo J., Kulkarni R.N., Kahn C.R., Kasai H., Cantley L.C., Kadowaki T. 2010. Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms. Cell Metab 12: 619-632.
    2. Sasaki, T., Kim, H-J., Kobayashi, M., Kitamura, Y-I., Yokota-Hashimoto, H., Shiuchi, T., Minokoshi, Y. and *Kitamura, T. 2010. Induction of Hypothalamic Sirt1 Leads to Cessation of Feeding via AgRP. Endocrinology 151: 2556-2566.
    3. Yamazaki, Y., Kamei, Y., Sugita, S., Akaike, F., Kanai, S., Miura, S., Hirata Y., Troen, BR., Kitamura, T., Nishino, I., Suganami, T., Ezaki, O., Ogawa, Y. 2010. The cathepsin L gene is a direct target of FOXO1 in the skeletal muscle. Biochem J 427: 171-178.
    4. 北村忠弘 2010　視床下部でのインスリン作用とその障害　ホルモンと臨床　5: 53-61.
    5. 北村忠弘 2010　FoxO1と糖尿病　International Review of Diabetes　2: 30-34.
    6. 北村忠弘、北村ゆかり 2010　FoxOファミリーとアディポサイエンス　アディポサイエンス　7: 127-133.
    7. Sasaki T. and Kitamura, T. 2010. Role of FoxO and Sirt1 in the central regulation of food intake. Endocrine Journal. 57: 939-946.
    8. 北村忠弘 2010　FoxO1と骨格筋分化　内分泌・糖尿病科・代謝内科　31: 478-485.
    9. 北村忠弘、小林雅樹、菊池司 2010　インスリンシグナル4) FoxO1による膵細胞量の調節　内分泌・糖尿病科　30:31-40.
    10. 北村忠弘、北村ゆかり 2010　FoxO1による代謝制御　Annual Review　98-104.
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