研究成果

[2014]

  1. Usui T, Kajita K, Kajita T, Mori I, Hanamoto T, Ikeda T, Okada H, Taguchi K, Kitada Y, Morita H, Sasaki T, Kitamura T, Sato T, Kojima I, Ishizuka T. Elevated mitochondrial biogenesis in skeletal muscle is associated with testosterone-induced body weight loss in male mice. FEBS Lett in press.
  2. Takamoto I, Kubota N, Nakaya K, Kumagai K, Hashimoto S, Kubota T, Inoue M, Kajiwara E, Katsuyama H, Obata A, Sakurai Y, Iwamoto M, Kitamura T, Ueki K and *Kadowaki T. TCF7L2 in pancreatic beta cells plays crucial roles in glucose homeostasis by regulating beta-cell mass. Diabetologia 57: 542-553. 2014.
  3. Sasaki T, Kikuchi O, Shimpuku M, Susanti V-Y, Yokota-Hashimoto H, Taguchi R, Shibusawa N, Sato T, Tang L, Amano K, Kitazumi T, Kuroko M, Fujita Y, Maruyama J, Lee Y-S, Kobayashi M, Nakagawa T, Minokoshi Y, Harada A, Yamada M and *Kitamura T. Hypothalamic Sirt1 prevents age-associated weight gain by improving leptin sensitivity in mice. Diabetologia 57: 819-831. 2014.
  4. Lee Y-S, Kobayashi M, Kikuchi O, Sasaki T, Kim H-J, Yokota-Hashimoto H, Susanti V-Y, Ido-Kitamura Y and *Kitamura T. ATF3 expression is induced by low glucose in pancreatic alpha and beta cells and regulates glucagon but not insulin gene transcription. Endocr J 61: 85-90. 2014.
  5. 北村忠弘 エネルギーホメオスターシスとFoxO1、Sirt1 最新肥満症学 72: 130-133.
  6. 北村忠弘 FoxO1を介した膵β細胞の脱分化 内分泌•糖尿病•代謝内科 38: 332-338.
  7. 北村忠弘 インスリンシグナルによる老化制御とアンチエイジング 最新医学 69: 998-1006.
  8. 北村忠弘 α細胞の解剖学、発生学 Diabetes Frontier 25: 158-163.
  9. 北村忠弘 グルカゴン•ルネッサンス 実験医学 32: 1268-1273.
  10. 北村忠弘 膵β細胞の分化、脱分化による量の調節機構 Annual Review 糖尿病•代謝•内分泌2014 1: 4-9.

[2013]

  1. *Kitamura T. The role of FOXO1 in b-cell failure and type 2 diabetes mellitus. Nat Rev Endo 9: 615-623. 2013.
  2. Fukaya M, Tamura Y, Chiba Y, Tanioka T, Mao J, Inoue Y, Yamada M, Waeber C, Ido-Kitamura Y, Kitamura T, *Kaneki M. Protective effects of a nicotinamide derivative, isonicotinamide, against streptozotocin-induced beta-cell damage and diabetes in mice. Biochem Bioph Res Co 442: 92-98. 2013.
  3. Syamsunarno MA, *Iso T, Hanaoka Y, Yamaguchi A, Obokata M, Koitabashi N, Goto K, Hishiki T, Nagahata Y, Matsui H, Sano M, Kobayashi M, Kikuchi O, Sasaki T, Maeda K, Murakami M, Kitamura T, Suematsu M, Tsushima Y, Endo K, Hotamisligil GS, Kurabayashi M. A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting. PLoS ONE 8: e79386. 2013.
  4. Sasaki T, Shimpuku M, Kitazumi T, Hiraga H, Nakagawa Y, Shibata H, Okamatsu-Ogura Y, Kikuchi O, Kim HJ, Fujita Y, Maruyama J, Susanti VY, Yokota-Hashimoto H, Kobayashi M, Saito M, *Kitamura T. Miglitol prevents diet-induced obesity by stimulating brown adipose tissue and energy expenditure independent of preventing the digestion of carbohydrates. Endocr J 60: 1117-1129. 2013.
  5. Lee Y-S, Sasaki T, Kobayashi M, Kikuchi O, Kim H-J, Yokota-Hashimoto H, Shimpuku M, Susanti V-Y, Ido-Kitamura Y, Kimura K, Inoue H, Tanaka-Okamoto M, Ishizaki H, Miyoshi J, Ohya S, Tanaka Y, Kitajima S and *Kitamura T. 2013. Hypothalamic ATF3 is involved in regulating glucose and energy metabolism. Diabetologia 56: 1383-1393.
  6. Masubuchi Y, Nakagawa Y, Ma J, Sasaki T, Kitamura T, Yamamoto Y, Kurose H, Kojima I, Shibata H. 2013. A novel regulatory function of sweet taste-sensing receptor in adipogenic differentiation of 3T3-L1 cells. PLoS ONE 8: e54500.
  7. Iwasaki Y, Shimomura K, Kohno D, Dezaki K, Ayush E, Nakabayashi H, Kubota K, Kadowaki T, Kakei M, Nakata M, Yada T. 2013 Insulin activates vagal afferent neurons including those innervating pancreas via insulin cascade and Ca2+ influx: its dysfunction in IRS2-KO mice with hyperphagic obesity. PLOS ONE in press.
  8. 北村忠弘 2013 膵β細胞量の調節機構 内科 113: 113-118.
  9. 北村忠弘 2013 膵β細胞量の調節におけるFoxO1の役割 Islet Equality 2: 23-29.
  10. 北村忠弘 2013 TOPICS糖尿病における膵β細胞機能不全のメカニズムとしてのβ細胞脱分化 Diabetes Strategy 3: 144-145.
  11. 北村忠弘 2013 海外文献紹介 Diabetes Frontier
  12. 北村忠弘 2013 変わりつつある糖尿病治療戦略について考える 高崎医学 63: 44-53.
  13. 北村忠弘 2013 消化管におけるFoxO1抑制による機能性インスリン産生細胞の樹立 糖尿病学2013 1-10.
  14. 北村忠弘 2013  FoxO1による腸管内分泌細胞分化制御 内分泌•糖尿病•代謝内科 36: 211-219.
  15. 北村忠弘 2013 肥満と中枢性エネルギー代謝調節機構 日本臨床 特集:肥満症 71: 217-223.

[2012]

  1. Kitamura YI, Sasaki T, Kobayashi M, Kim H-J, Lee Y-S, Kikuchi O, Yokota-Hashimoto H, Iizuka K, Accili D, *Kitamura T. 2012. Hepatic FoxO1 Integrates Glucose Utilization and Lipid Synthesis Through Regulation of Chrebp O-glycosylation. PLoS ONE 7: e47231.
  2. Nakakura T, Mogi C, Tobo M, Tomura H, Sato K, Kobayashi M, Ohnishi H, Tanaka S, Wayama M, Sugiyama T, Kitamura T, Harada A, Okajima F. 2012. Deficiency of Proton-Sensing Ovarian Cancer G Protein-Coupled Receptor 1 Attenuates Glucose-Stimulated Insulin Secretion. Endocrinology 153: 4171-4180.
  3. Hasegawa K, Kawahara T, Fujiwara K, Shimpuku M, Sasaki T, Kitamura T, Yoshikawa K. 2012. Necdin controls Foxo1 acetylation in hypothalamic arcuate nucleus to modulate the thyroid axis. J Neuroscience 32: 5562-5572.
  4. Talchai C, Xuan S, Kitamura T, Depinho RA, Accili D.2012. Generation of functional insulin-producing cells in the gut by Foxo1 ablation. Nat Genet 44: 406-412.
  5. Kikuchi O, Kobayashi M, Amano K, Sasaki T, Kitazumi T, Kim H-J, Lee Y-S, Yokota-Hashimoto H, Kitamura Y-I and *Kitamura T. 2012. FoxO1 Gain of Function in the Pancreas Causes Glucose Intolerance, Polycystic Pancreas, and Islet Hypervascularization. PLoS ONE 7: e32249.
  6. Kobayashi M, Kikuchi O, Sasaki T, Kim HJ, Yokota-Hashimoto H, Lee YS, Amano K, Kitazumi T, Susanti VY, Kitamura YI, *Kitamura T. 2012. FoxO1 as a Double-edged Sword in the Pancreas: Analysis of Pancreas and β Cell-specific FoxO1 Knockout Mice. Am J Physiol Endocrinol Metab. 302: E603-613.
  7. Kim H-J., Kobayashi M., Sasaki T., Kikuchi O., Amano K., Kitazumi T., Lee Y-S., Yokota-Hashimoto H., Susanti V-Y., Ido-Kitamura Y., Nakae J. and *Kitamura T. 2012. Over-expression of FoxO1 in the Hypothalamus and Pancreas Causes Obesity and Glucose Intolerance. Endocrinology 153: 659-671.
  8. *Kitamura T. and Sasaki T. 2012. Hypothalamic Sirt1 and regulation of food intake. Diabetology International 3: 109-112.
  9. Kim KW, Donato J Jr, Berglund ED, Choi YH, Kohno D, Elias CF, DePinho RA, Elmquist JK. 2012. FoxO1 Regulates Energy Balance and Glucose Homeostasis in Neurons in the Ventral Medial Nucleus of the Hypothalamus. J Clin Invest 122: 2578-2589.
  10. Kohno D, Yada T. 2012. Arcuate NPY neurons sense and integrate peripheral metabolic signals to control feeding. Neuropeptides 46: 315-319.

[2011]

  1. Tanioka T., Tamura Y., Fukaya M., Shinozaki S., Mao J., Kim M., Shimizu N., Kitamura T. and Kaneki M. 2011. iNOS and NO donor decrease IRS-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta cells: involvement of GSK-3b. J. Biol. Chem. 286: 29388-29396.
  2. Hirata M., Suzuki M., Ishii R., Kitazumi T., Sasaki T., Kitamura T., Yamaguchi H., Nakamura Y. and Fukami K. 2011. Genetic defect in phospholipase Cδ1 protects mice from obesity by regulating thermogenesis and adipogenesis. Diabetes 60: 1926-1937.
  3. Maejima Y, Kohno D, Iwasaki Y, Yada T.2011. Insulin suppresses ghrelin-induced calcium signaling in neuropeptide Y neurons of the hypothalamic arcuate nucleus. Aging (Albany NY) 3:1092-1097.
  4. Chuang JC, Sakata I, Kohno D, Perello M, Osborne-Lawrence S, Repa JJ, Zigman JM. 2011. Ghrelin Directly Stimulates Glucagon Secretion from Pancreatic a-Cells. Mol Endocrinol. 25:1600-1611.
  5. Kohno D, Sone H, Tanaka S, Kurita H, Gantulga D, Yada T. 2011. AMP-activated protein kinase activates neuropeptide Y neurons in the hypothalamic arcuate nucleus to increase food intake in rats. Neurosci Lett. 499, 194-198.
  6. Kim KW, Zhao L, Donato J Jr, Kohno D, Xu Y, Elias CF, Lee C, Parker KL, Elmquist JK. 2011. Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus. Proc Natl Acad Sci U S A 108, 10673-10678.
  7. 北村忠弘 2011  FoxO1とエネルギー代謝 BIO Clinica  26: 18-24.
  8. 北村忠弘 2011 膵β細胞の分化、増殖制御と糖尿病治療 細胞 43: 2-4.
  9. 北村忠弘、佐々木努 2011 POMC/CART(視床下部におけるFoxO1とSirt1)生体の科学 62: 26-30.
  10. 北村忠弘、北村ゆかり 2011 PPARファミリー、C/EBPファミリー、FoxOファミリー 日本臨床Ÿ増刊号メタボリックシンドローム 69: 259-263.
  11. *Kitamura T. , Kitamura Y., Accili D. 2011. Role of FoxO1 proteins in pancreatic b cells. Islet Cell Growth Factors. Chapter 6, 73-83.

[2010]

  1. Kaneko K., Ueki K., Takahashi N., Hashimoto S., Okamoto M., Awazawa M., Okazaki Y., Ohsugi M., Inabe K., Umehara T., Yoshida M., Kakei M., Kitamura T., Luo J., Kulkarni R.N., Kahn C.R., Kasai H., Cantley L.C., Kadowaki T. 2010. Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms. Cell Metab 12: 619-632.
  2. Sasaki, T., Kim, H-J., Kobayashi, M., Kitamura, Y-I., Yokota-Hashimoto, H., Shiuchi, T., Minokoshi, Y. and *Kitamura, T. 2010. Induction of Hypothalamic Sirt1 Leads to Cessation of Feeding via AgRP. Endocrinology 151: 2556-2566.
  3. Yamazaki, Y., Kamei, Y., Sugita, S., Akaike, F., Kanai, S., Miura, S., Hirata Y., Troen, BR., Kitamura, T., Nishino, I., Suganami, T., Ezaki, O., Ogawa, Y. 2010. The cathepsin L gene is a direct target of FOXO1 in the skeletal muscle. Biochem J 427: 171-178.
  4. 北村忠弘 2010 視床下部でのインスリン作用とその障害 ホルモンと臨床 5: 53-61.
  5. 北村忠弘 2010 FoxO1と糖尿病 International Review of Diabetes 2: 30-34.
  6. 北村忠弘、北村ゆかり 2010 FoxOファミリーとアディポサイエンス アディポサイエンス 7: 127-133.
  7. Sasaki T. and Kitamura, T. 2010. Role of FoxO and Sirt1 in the central regulation of food intake. Endocrine Journal. 57: 939-946.
  8. 北村忠弘 2010 FoxO1と骨格筋分化 内分泌Ÿ糖尿病科Ÿ代謝内科 31: 478-485.
  9. 北村忠弘、小林雅樹、菊池司 2010 インスリンシグナル4) FoxO1による膵b細胞量の調節 内分泌Ÿ糖尿病科 30:31-40.
  10. 北村忠弘、北村ゆかり 2010 FoxO1による代謝制御 Annual Review 98-104.
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